Beilstein J. Org. Chem.2013,9, 1601–1606, doi:10.3762/bjoc.9.182
neuraminidase (NA) inhibitor, was synthesized by using a bioinspired, organocatalytic enantioselective 1,4-conjugate addition of styryl-2-pyranone with cinnamaldehyde, followed by a tandem Horner–Wadsworth–Emmons/oxa Michael addition.
Keywords: bioinspiredsynthesis; catalysis; katsumadain A; natural product
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Graphical Abstract
Scheme 1:
Proposed biosynthetic pathway and strategic analysis for synthesis of katsumadain A.